SECURITY Did Not Establish Noninferiority

How Einstein Did Not Discover

What powered Einstein’s discoveries? Was it asking naïve questions, stubbornly? Was it a mischievous urge to break rules? Was it the destructive power of operational thinking? It was none of these. Rather, Einstein made his discoveries through lengthy, mundane investigations, pursued with tenacity and discipline. We have been led to think otherwise in part through Einstein’s brilliance at recou...

Noninferiority trials

Noninferiority trials are intended to show that the effect of a new treatment is not worse than that of an active control by more than a specified margin. These trials have a number of inherent weaknesses that superiority trials do not: no internal demonstration of assay sensitivity, no single conservative analysis approach, lack of protection from bias by blinding, and difficulty in specifying...

Why HP did not get "Blastered"

In August 2003 the IT industry was brought to its knees due to the release of a vicious worm called “Blaster” which cost the industry billions of dollars. However, HP was largely unaffected because of innovative technology produced jointly by HP Labs and Corporate IT that has been protecting our corporate network for over two years. In this paper we will explain how these new types of worms att...

The HCV Revolution Did Not Happen Overnight

The progress in HCV therapy in the last three years is similar to the progress that took HIV therapy ∼14 years. We are at the brink of approval for an all-oral drug combination that is dosed once daily as a single pill, has >95% efficacy, and is well tolerated. This article summarizes the path to this success and the challenges still ahead.

Bonaparte Did Not Die of Cancer